Two Palestinians were shot and injured with live bullets, while three others were injured with rubber-coated steel bullets during clashes in Bethlehem on Tuesday, the Palestinian Authority Ministry of Health said.
The ministry said two protesters were shot with live bullets in their lower extremities, while one of those shot with a rubber-coated steel bullet was hit in the face.
The conditions of the five are unknown.
An Israeli army spokesperson did not immediately respond for comment.
Clashes at the northern entrance of Bethlehem have been a nearly daily occurrence since the start of October, amid increased tensions in the area.
Rights groups have long criticized Israel's excessive use of force when responding to demonstrations in the occupied Palestinian territory.
In the West Bank, UN Office for Humanitarian affairs reported that the total number of Palestinian injuries from Oct. 1 to Nov. 9 alone had far surpassed the total number injured during the whole of 2014.
Over 7,000 Palestinians have been injured since the start of October, and 83 have been killed.