PFC Ludogorets and Liverpool hold up the bottom of their group and they will both hope for Real Madrid to crush FC Basel so that a victory of either of them could perhaps spell their chance to escape to the next round of the UEFA Champions League.
Ludogorets have only lost once at home this season, and although this match will be played at a stadium other than their own home turf, but their form continues to be strong.
Liverpool on the other hand have now lost four straight matches after their crumbling defeat at Selhurst Park over the weekend. Brendan Rodgers has much to do to get his side in order as a defeat on Wednesday could signal his true downfall.
The loss of Daniel Sturridge yet again looks to only have complicated an already desperate situation and injuries as well have claimed Mario Balotelli leaving the strike force for the Reds down to Fabio Borini and Rickie Lambert whom have only Lambert's weekend goal between them in all competitions this season.
Projected Lineups
Ludogorets XI: Stoyanov: Caicara, Terziev, Moti, Minev; Aleksandrov, Anicet, Dyakov, Espinho, Abalo; Marcelinho.
Liverpool XI: Mignolet: Manquillo, Lovren, Skrtel, Moreno; Leiva, Gerrard, Henderson; Sterling, Lambert, Lallana.