The northern part of the rebel enclave in eastern Aleppo has fallen to government forces, the Syrian Observatory for Human Rights says.
Rebels have lost 30 per cent of the besieged enclave since Saturday, in their worst defeat since they seized the east of the city in 2012, Observatory director Rami Abdel-Rahman tells dpa.
Rebel defences in the northern part of the enclave appear to have collapsed suddenly after holding up during a five-month siege. The government's push was broken only for a few weeks by rebel forces who fought their way in from outside the city in August.
Eastern Aleppo has been devastated by four years of heavy government shelling and airstrikes, which have repeatedly hit civilian facilities and, according to the charity Doctors without Borders, put at least eight of the area's nine hospitals out of action.